The differences between TMS and antidepressants

Antidepressants work by modifying the actions of neurotransmitters (brain chemicals) or by modifying neurotransmitter receptors.

TMS (Transcranial Magnetic Stimulation) induces small electrical currents in the brain that improve connections between brain cells and increase brain cell growth.

Treatment with antidepressants involves taking medications that are absorbed through the mouth, stomach, and small intestine, with potential side effects throughout the body. These can cause adverse effects such as gastrointestinal discomfort, weight gain, and may affect sexual function (decreased libido and delayed ejaculation).

Patients may also be allergic to antidepressants or other chemicals contained in the medication.

Benefits of TMS compared to Antidepressants

Transcranial magnetic stimulation does not involve the ingestion of chemicals; therefore, there are no systemic adverse effects. There is no impact on the digestive system, sexual function, or cognition, and there are no allergic reactions.

The only side effect of TMS that occurs in more than 5% of patients is transient pain at the stimulation site, often a headache, which usually subsides within the first week as patients become desensitized to the treatment.

Antidepressants alter brain chemicals and receptors by affecting protein synthesis; they can take three to six weeks to work, while TMS has a faster onset of action.

Studies show that in patients who have not responded to two or three antidepressants, the response rate to the next antidepressant is 10–15%.

If these patients are given TMS, the response rate is approximately 60%.