Innovative, non-invasive treatments for depression and other conditions, provided by certified healthcare professionals
We offer state-of-the-art Transcranial Magnetic Stimulation (TMS), which uses magnetic fields to stimulate neurons and activate specific brain areas, as well as ketamine infusions, which act on brain chemicals such as glutamate, increasing neuronal connectivity and promoting neuroplasticity.
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How it works
How does the Transcranial Magnetic Stimulation works?
Transcranial Magnetic Stimulation (TMS) uses a magnetic field to stimulate specific areas of the brain.
After placing a coil directly on the patient's head, a magnetic field is generated to stimulate neurons in the targeted brain region.
This process is non-invasive, painless, and highly localized, so it doesn't affect the entire body system like oral medications and has few short-term side effects.
Long-term side effects are unknown. The most common side effect is some discomfort in the treatment area, which usually disappears within a few hours.
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Transcranial Magnetic Stimulation consists of 20 to 36 treatment sessions, five days a week, for six to seven weeks, with each session lasting between 20 and 30 minutes.
The process
In the first session, the doctor develops the treatment protocol based on the patient's diagnosis. According to the established protocol, the area where the coil will be placed and the number of magnetic pulses will be determined.
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Once this area to be stimulated is identified, the coil will be placed directly on the head while the patient is seated in a chair. The patient will be awake and alert throughout the treatment.
​After the procedure, the patient can resume their normal activities (exercising, driving, working).
Contraindications
Patients with body electronic devices (implantable defibrillators, vagus nerve stimulators, deep brain stimulation electrodes, insulin pumps, etc.), intracranial ferromagnetic elements (plates, screws, ventriculoperitoneal shunt valves, stents, jewelry, cochlear implants).
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1. Major Depressive Disorder
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Study 1: High-frequency repetitive Transcranial Magnetic Stimulation accelerates and improves clinical response to antidepressants in major depression: a meta-analysis of randomized, double-blind, sham-controlled trials.
High-frequency repetitive transcranial magnetic stimulation accelerates and enhances the clinical response to antidepressants in major depression: a meta-analysis of randomized, double-blind, and sham-controlled trials.
https://pubmed.ncbi.nlm.nih.gov/23473357/
**Berlim MT, Van den Eynde F, Daskalakis ZJ. High-frequency repetitive transcranial magnetic stimulation accelerates and enhances the clinical response to antidepressants in major depression: a meta-analysis of randomized, double-blind, and sham-controlled trials. J Clin Psychiatry. 2013 Feb;74(2):e122-9. doi: 10.4088/JCP.12r07996. PMID: 23473357.
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Study 2: Clinically meaningful efficacy and acceptability of low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) for the treatment of primary major depression: a meta-analysis of randomized, double-blind, sham-controlled trials.
Clinically Meaningful Efficacy and Acceptability of Low-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) for Treating Primary Major Depression: A Meta-Analysis of Randomized, Double-Blind and Sham-Controlled Trials.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572468/
**Berlim MT, Van den Eynde F, Jeff Daskalakis Z. Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating primary major depression: a meta-analysis of randomized, double-blind and sham-controlled trials. Neuropsychopharmacology. 2013 Mar;38(4):543-51. doi: 10.1038/npp.2012.237. Epub 2012 Nov 19. PMID: 23249815; PMCID: PMC3572468.
2. Bipolar disorder
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Study 1: The efficacy and safety of transcranial magnetic stimulation in treatment-resistant bipolar depression.
The Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression.
https://pubmed.ncbi.nlm.nih.gov/35772133/
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**Zengin G, Topak OZ, Atesci O, Culha Atesci F. The Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression. Psychiatr Danub. 2022 Summer;34(2):236-244. doi: 10.24869/psyd.2022.236. PMID: 35772133.
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Study 2: Brain stimulation treatment for bipolar disorder.
Brain stimulation treatment for bipolar disorder.
https://pubmed.ncbi.nlm.nih.gov/36515461/
**Mutz J. Brain stimulation treatment for bipolar disorder. Bipolar Disord. 2023 Feb;25(1):9-24. doi: 10.1111/bdi.13283. Epub 2022 Dec 21. PMID: 36515461; PMCID: PMC10210071.
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3. Autism
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Study 1: Transcranial magnetic stimulation in autism spectrum disorders: neuropathological foundations and clinical correlations.
Transcranial Magnetic Stimulation in Autism Spectrum Disorders: Neuropathological Underpinnings and Clinical Correlations.
https://pubmed.ncbi.nlm.nih.gov/32892959/
**Casanova MF, Sokhadze EM, Casanova EL, Li X. Transcranial Magnetic Stimulation in Autism Spectrum Disorders: Neuropathological Underpinnings and Clinical Correlations. Semin Pediatr Neurol. 2020 Oct;35:100832. doi: 10.1016/j.spen.2020.100832. Epub 2020 Jun 24. PMID: 32892959; PMCID: PMC7477302.
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Study 2: Transcranial magnetic stimulation in autism spectrum disorders: neuropathological foundations and clinical correlations.
Treatment of Executive Function Deficits in autism spectrum disorder with repetitive transcranial magnetic stimulation: A double-blind, sham-controlled, pilot trial.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129776/
**Ameis SH, Blumberger DM, Croarkin PE, Mabbott DJ, Lai MC, Desarkar P, Szatmari P, Daskalakis ZJ. Treatment of Executive Function Deficits in autism spectrum disorder with repetitive transcranial magnetic stimulation: A double-blind, sham-controlled, pilot trial. Brain Stimul. 2020 May-Jun;13(3):539-547. doi: 10.1016/j.brs.2020.01.007. Epub 2020 Jan 15. PMID: 32289673; PMCID: PMC8129776.
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Study 3: Repetitive transcranial magnetic stimulation for the treatment of executive function deficits in autism spectrum disorder: a clinical trial approach.
Repetitive Transcranial Magnetic Stimulation for the Treatment of Executive Function Deficits in Autism Spectrum Disorder: Clinical Trial Approach.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510034/
**Ameis SH, Daskalakis ZJ, Blumberger DM, Desarkar P, Drmic I, Mabbott DJ, Lai MC, Croarkin PE, Szatmari P. Repetitive Transcranial Magnetic Stimulation for the Treatment of Executive Function Deficits in Autism Spectrum Disorder: Clinical Trial Approach. J Child Adolesc Psychopharmacol. 2017 Jun;27(5):413-421. doi: 10.1089/cap.2016.0146. Epub 2017 Mar 27. PMID: 28346865; PMCID: PMC5510034.
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4. Neuropathic pain
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Study 1: Effects of repetitive transcranial magnetic stimulation on neuropathic pain: a systematic review and meta-analysis.
Effects of repetitive transcranial magnetic stimulation on neuropathic pain: A systematic review and meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/34826512/
**Jiang X, Yan W, Wan R, Lin Y, Zhu X, Song G, Zheng K, Wang Y, Wang X. Effects of repetitive transcranial magnetic stimulation on neuropathic pain: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2022 Jan;132:130-141. doi: 10.1016/j.neubiorev.2021.11.037. Epub 2021 Nov 24. PMID: 34826512.
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Study 2: High-frequency repetitive transcranial magnetic stimulation therapy for chronic neuropathic pain: a meta-analysis.
High Frequency Repetitive Transcranial Magnetic Stimulation Therapy For Chronic Neuropathic Pain: A Meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/26606017/
**Jin Y, Xing G, Li G, Wang A, Feng S, Tang Q, Liao X, Guo Z, McClure MA, Mu Q. High Frequency Repetitive Transcranial Magnetic Stimulation Therapy For Chronic Neuropathic Pain: A Meta-analysis. Pain Physician. 2015 Nov;18(6):E1029-46. PMID: 26606017.
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5. Stroke
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Study 1: Current evidence on transcranial magnetic stimulation and its potential usefulness in post-stroke neurorehabilitation: Opening new doors to the treatment of cerebrovascular disease.
https://pubmed.ncbi.nlm.nih.gov/27161423/
León Ruiz M, Rodríguez Sarasa ML, Sanjuán Rodríguez L, Benito-León J, García-Albea Ristol E, Arce Arce S. Current evidence on transcranial magnetic stimulation and its potential usefulness in post-stroke neurorehabilitation: Opening new doors to the treatment of cerebrovascular disease. Neurologia (Engl Ed). 2018 Sep;33(7):459-472. English, Spanish. doi: 10.1016/j.nrl.2016.03.008. Epub 2016 May 6. PMID: 27161423.
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6. Epileps
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Study 1: Transcranial magnetic stimulation for the diagnosis and treatment of epilepsy.
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Transcranial magnetic stimulation for the diagnosis and treatment of epilepsy.
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**Kimiskidis, Vasilios K.a; Valentin, Antoniob,c; Kälviäinen, Reettad. Transcranial magnetic stimulation for the diagnosis and treatment of epilepsy. Current Opinion in Neurology 27(2):p 236-241, April 2014. | DOI: 10.1097/WCO.0000000000000071.
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7. Anxiety
Study 1: Transcranial magnetic stimulation in anxiety and trauma-related disorders: a systematic review and meta-analysis.
Transcranial magnetic stimulation in anxiety and trauma-related disorders: A systematic review and meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/31066227/
**Cirillo P, Gold AK, Nardi AE, Ornelas AC, Nierenberg AA, Camprodon J, Kinrys G. Transcranial magnetic stimulation in anxiety and trauma-related disorders: A systematic review and meta-analysis. Brain Behav. 2019 Jun;9(6):e01284. doi: 10.1002/brb3.1284. Epub 2019 May 7. PMID: 31066227; PMCID: PMC6576151.
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Study 2: Repetitive transcranial magnetic stimulation for generalized anxiety and panic disorders: a systematic review and meta-analysis.
Repetitive transcranial magnetic stimulation for generalized anxiety and panic disorders: A systematic review and meta-analysis.
https://pubmed.ncbi.nlm.nih.gov/35550035/
**Cox J, Thakur B, Alvarado L, Shokar N, Thompson PM, Dwivedi AK. Repetitive transcranial magnetic stimulation for generalized anxiety and panic disorders: A systematic review and meta-analysis. Ann Clin Psychiatry. 2022 May;34(2):e2-e24. doi: 10.12788/acp.0050. PMID: 35550035.
